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Apoptosis detected by flow cytometry. Apoptosis rate in the HIF-1α-miRNA group was significantly higher than in groups treated with Scrambled, untreated or survivin plasmid + miRNA (P<0.05) under hypoxia; however, the effect of HIF-1α-miRNA on apoptosis under normoxia did not differ significantly between the Scrambled and untreated groups (data not shown).
