Table I.
Distinct expression of certain IGF-1 signaling components when comparing VSELs and HSCs.
| Gene name | Gene symbol | Fold-change | P-value |
|---|---|---|---|
| Jun oncogene | JUN | −189.129 | 5.24E-07 |
| FBJ murine osteosarcoma viral oncogene homolog | FOS | −125.22 | 7.12E-07 |
| Janus kinase 1 | JAK1 | −34.637 | 2.56E-05 |
| V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | KRAS | −31.333 | 2.90E-05 |
| Son of sevenless homolog 2 (Drosophila) | SOS2 | −19.808 | 6.88E-04 |
| Serum response factor | SRF | −14.406 | −14.406 |
| Suppressor of cytokine signaling 3 | SOCS3 | −12.740 | 1.01E-05 |
| Growth factor receptor-bound protein 2 | GRB2 | −4.005 | 2.07E-04 |
| SHC (Src homology 2 domain containing) transforming protein 1 | SHC1 | −3.096 | 1.60E-03 |
| Mitogen-activated protein kinase kinase 1 | MAP2K1 | −2.483 | 6.15E-03 |
| V-akt murine thymoma viral oncogene homolog 3 | AKT3 | −2.306 | 8.82E-02 |
Fold-change and P-values were calculated from the microarray data for the comparisin between VSELs and HSCs. The genes are ordered by the fold-changes in VSELs vs. HSCs. IGF-1, insulin-like growth factor-1; VSELs, very small embryonic-like stem cells; HSCs, hematopoietic stem cells.