. 2013 Sep 18;8(9):e74719. doi: 10.1371/journal.pone.0074719

Table 3. Comparison of Key Ca²⁺ Handling Mechanisms in Hearts and Cardiomyocytes From Young Adult OVX and Aged OVX Female Mice.

Parameter	*YoungOVX*	*YoungOVX*	*AgedOVX*	*AgedOVX*
	Relativetosham	*% change*	Relativetosham	*% change*
Ca²⁺ transient, peak	⬆	106	⬆	91
Ca²⁺ transient, rate of rise	⬆	54	⬆	43
Ca²⁺ transient, rate of decay	⬆	113	⬆	71
Ca²⁺ current	⬌	⬌	⬆	48
Gain of SR Ca²⁺ release	⬆	112	⬌	⬌
SR Ca²⁺ content	⬆	83	⬆	90
Diastolic Ca²⁺	⬌	⬌	⬌	⬌
Ca²⁺ spark frequency	⬆	25	⬆	76
Ca²⁺ spark amplitude	⬆	11	⬆	43
Ca²⁺ spark width	⬌	⬌	⬆	22
Ca²⁺ spark duration	⬌	⬌	⬌	⬌
RMP			⬌	⬌
APD₅₀, APD₉₀			⬌	⬌
Myocyte contraction, peak			⬌	⬌
Myocyte contraction, time to peak			⬇	18
Myocyte contraction, time to 50% relaxation			⬇	25
Fractional shortening, in vivo			⬌	⬌
Ejection fraction, in vivo			⬌	⬌
Heart rate, in vivo			⬌	⬌
Maximum actomyosin ATPase activity			⬌	⬌
Myofilament Ca²⁺ sensitivity (EC₅₀)			⬇	26
Ca_v1.2 expression			⬇	70
NCX expression			⬌	⬌
SERCA2 expression			⬌	⬌

Young adult data are from reference [15]. ⬆ or ⬇ represents increase or decrease relative to age-matched sham control. ⬌ represents no change relative to age-matched sham control. The magnitude of change for each parameter relative to age-matched sham controls is indicated in the column entitled "% change".

Table 3. Comparison of Key Ca2+ Handling Mechanisms in Hearts and Cardiomyocytes From Young Adult OVX and Aged OVX Female Mice.

Table 3. Comparison of Key Ca²⁺ Handling Mechanisms in Hearts and Cardiomyocytes From Young Adult OVX and Aged OVX Female Mice.