Figure 1. Disruption of 5-HT2A receptor/PDZ protein interactions produces anti-hyperalgesic effects in carrageenan-injected rats.
Carrageenan-treated hyperalgesic rats were injected with either TAT-2ASCV (30, 100 ng/rat) or TAT-2ASCA (100 ng /rat) or NaCl (10 µl/rat). The vocalization thresholds to paw-pressure were measured up to 75 min after the injection (A). **P<0.01 and ***P<0.001, compared with values measured before the peptide/NaCl injection (time 0). (B) Area under the time-course (0-60 minutes) of vocalization threshold variations. ***P<0.001 vs. NaCl-treated group.