Figure 8. Schematic for the generation of νCs.

(A) Generation of recurrent delta ripples within hippocampal neurons fails to activate the dentate gyrus. At right: hippocampal field potential activity. (B) Increased synchronization of delta ripples activates dentate gyrus granule cells, which in turn recruit hippocampal neurons, creating a νC. At right, entorhinal cortex field potential activities (green). (C) The newly generated νC activates cortically-projecting deep layers of the entorhinal cortex, permitting the propagation of the νC toward the neocortex. At right, scalp EEG activity.