Table 1. Phospho-sites identified in mouse CFTR expressed in yeast.
phospho-residue number | ||||||
Mouse CFTR (P26361) | Human CFTR (P13569) | Domain | Sequence (mouse) | Phosphorylatedin vivo | Phosphorylated in vitro by PKA | Phosphorylated in vitro by CK2 |
S670 | S670 | R-domain | TETLRRFSVDDSSAP | [6] | [9] | |
S698 | S700 | R-domain | VGEKRKNSILNSFSS | [6], [7] | [5], [6] | |
S710 | S712 | R-domain | FSSVRKISIVQKTPL | [6], [7] | [5], [6] | |
S723 | S728 | R-domain | PLCIDGESDDLQEKR | |||
S732 | S737 | R-domain | DLQEKRLSLVPDSEQ | [6], [7] | [5], [6] | |
S737 | S742 | R-domain | RLSLVPDSEQGEAAL | |||
S763 | S768 | R-domain | FPGRRRQSVLDLMTF | [6] | [5], [6] | |
S790 | S795 | R-domain | RTSIRKISLVPQISL | [6], [7] | [5], [6] | |
S808 | S813 | R-domain | DVYSRRLSQDSTLNI | [5], [6] | ||
S811 | T816 | R-domain | SRRLSQDSTLNITEE | |||
S1183 | – | – | KELPREGSSDVLVIKN | |||
T1467 | T1471 | C-term | ITALKEETEEEVQET | This paper |