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. 2013 Sep 18;8(9):e74347. doi: 10.1371/journal.pone.0074347

Figure 1. CFTR and its domains.

Figure 1

A. Ribbon diagram of CFTR. NBD1 interacts with NBD2 and intracellular coupling helices, such as CL4. The disordered regulatory insert (RI) of NBD1 and the R region, which follows helices H8/H9 of NBD1, are sites of phosphor-regulation of the channel. B. NBD1 viewed from the NBD1:NBD2 interface. Residue F508 is in the CL4-binding site predicted by homology models [8], [9]. The figures were rendered with PyMOL [81] using a CFTR homology model [9]. The regulatory insert was modeled as a smoothed loop.