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Modulation of IGFBP-3 by HN analogues in WT mice. WT mice received ip injection with either HNG or HNGF6A, and IGFBP-3 levels were subsequently measured (HNG, dotted line; HNGF6A, hatched line). Following injection with HNG, IGFBP-3 levels decreased to 80% of baseline after 180 minutes (dotted line) (P < .01). After injection with HNGF6A, IGFBP-3 levels remained unchanged in these mice (hatched line).
