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. 2013 Jul 8;154(10):3739–3744. doi: 10.1210/en.2012-2004

Figure 4.

Figure 4.

Modulation of IGF-1 by HN analogues in WT and IGFBP-3−/− mice. Following ip injection with HN analogues, IGF-1 levels were measured in the 3 treatment groups: WT mice treated with HNG (circles), WT mice treated with HNGF6A (squares), and IGFBP-3−/− mice treated with HNG (triangles). After treatment with HNG, IGF-1 levels in WT mice decreased by 23% (circles) (P < .01). In contrast, IGF-1 levels remained unchanged in the IGFBP-3−/− mice injected with HNG (triangles), and in WT mice injected with HNGF6A (squares).