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. 2013 Jul 8;154(10):3739–3744. doi: 10.1210/en.2012-2004

Figure 5.

Figure 5.

Plasma HN levels in sprague dawley rats. Error bars represent the 95% confidence intervals. Rats received an ip injection with HNG 4 mg/kg, and HN levels were measured in plasma with ELISA. Shown is a best-fit curve of the kinetic data as well as mean values of HN levels at the first 4 hours and at 24 hours (P < .05). Pooling the data from the first 3 time points, the average serum level is significantly higher than that of the averaged data at the 24th hour (6.8 ng/mL ± 1.3 compared with 2.7 ng/mL ± 1.3) (P < .05). The sample size for the first 3 time points group is 10 rats, and sample size for the 24th hour group is 4 rats. The half-life of HN appears to be greater than 4 hours, which is much longer than the half-life measured in mice (<1 hour).