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(A) Overall survival in patients according to Köhne's risk classification (FIRE-1 trial population; n=479). (B) Overall survival according to FIRE prognostic score (LDH + WBC) (LLD population). (C) Overall survival according to FIRE prognostic score (LDH + WBC) (FIRE-1 trial population). Abbreviations: Low risk=WBC count and LDH levels not elevated; Intermediate risk=WBC count or LDH levels elevated; High risk=WBC count and LDH levels elevated; OS=overall survival.
