Table 7. Overall survival according to WBC and LDH (FIRE score).
| |
Low risk |
Intermediate risk |
High risk |
P-value |
|||
|---|---|---|---|---|---|---|---|
| Overall survival | Median | 95% CI* | Median | 95% CI* | Median | 95% CI* | Log-rank |
| LLD patients (n=215) |
23.2 |
18.1–28.1 |
16.7 |
13.2–20.1 |
10.1 |
5.9–14.4 |
<0.001 |
| FIRE-1 trial (n=479) | 25.2 | 22.9–27.6 | 17.4 | 15.3–19.4 | 10.6 | 7.8–13.8 | <0.001 |
Abbreviations: CI=confidence interval; High risk=WBC and LDH elevated; Intermediate risk=WBC or LDH elevated; LLD=liver-limited disease; Low risk=WBC and LDH not elevated; OS=overall survival.
*The P-value given in the last row of the table reflects the global log-rank P-value over the three subgroups.