Table 5. Diagnostic performances of validated AFP at 400 U l−1 to discriminate 537 patients with HCC from patients with non-malignant chronic liver diseases (n=1671).
| Classification | Sen % | Spe % | PPV% | NPV% | AC% | AUC |
|---|---|---|---|---|---|---|
| F0 (N=153) vs HCC | 54 | 100 | 100 | 30 | 62 | 0.70 |
| F1–F3 (N=1073) vs HCC | 40 | 100 | 100 | 83 | 84 | 0.70 |
| Liver cirrhosis child A (no 420 ) vs HCC | 54 | 99 | 99 | 63 | 74 | 0.77 |
| Liver cirrhosis child B (no 25) vs HCC Aged 65±3.8 years | 59 | 100 | 100 | 30 | 64 | 0.73 |
| Total liver cirrhosis (no= 445) vs HCC |
54 |
99 |
98 |
64 |
74 |
0.77 |
|
Number of nodules (no., %) | ||||||
| Single (388; 72.3%) | 55 | 99 | 99 | 72 | 72 | 0.72 |
| Multiple (149, 27.7% ) |
52 |
99 |
95 |
86 |
77 |
0.69 |
|
Vascular invasion (no., %) | ||||||
| Absent (528, 98.3%) | 46 | 99 | 98 | 61 | 70 | 0.71 |
| Present (10, 0.7%) |
66 |
99 |
60 |
99 |
74 |
0.79 |
|
Size of nodules (no., %) | ||||||
| <2 (18, 4%) | 57 | 99 | 96 | 88 | 87 | 0.71 |
| ⩾2 (516, 96%) |
67 |
99 |
99 |
72 |
82 |
0.71 |
|
CLIP score | ||||||
| 0–1 ( 128, 24%) | 1 | 99 | 20 | 77 | 77 | 0.5 |
| ⩾2 (409, 76%) | 71 | 99 | 99 | 79 | 97 | 0.8 |
Abbreviations: AC=accuracy; ART=α-fetoprotein-routine test; AUC=area under (ROC) curve; CLIP=Cancer of the Liver Italian Program; HCC=hepatocellular carcinoma; NPV=negative predictive value; PPV=positive predictive value; Sen=sensitivity; Spe=specificity.