Table 6. Diagnostic performances of validated simplified HCC-ART score to discriminate 537 patients with HCC from patients with non-malignant chronic liver diseases (n=1671).
| Classification | Sen (%) | Spe (%) | PPV (%) | NPV (%) | AC (%) | AUC |
|---|---|---|---|---|---|---|
| F0 (N=153) vs HCC | 87 | 100 | 100 | 60 | 89 | 0.99 |
| F1–F3 (N=1073) vs HCC | 99 | 99 | 94 | 95 | 0.98 | |
| Liver cirrhosis child A (no 420) vs HCC | 84 | 88 | 84 | 86 | 0.91 | |
| Liver cirrhosis child B (no 25) vs HCC | 56 | 98 | 17 | 86 | 0.85 | |
| Total liver cirrhosis (no=445) vs HCC Aged 65±3.8 years |
|
83 |
86 |
84 |
95 |
0.91 |
|
Number of nodules (no., %) | ||||||
| Single (388, 72.3%) | 87 | 83 | 81 | 88 | 85 | 0.91 |
| Multiple (149, 27.7%) |
87 |
83 |
63 |
95 |
84 |
0.91 |
|
Vascular invasion (no., %) | ||||||
| Absent (528, 98.3%) | 88 | 83 | 86 | 84 | 85 | 0.91 |
| Present (10, 0.7%) |
100 |
83 |
11 |
100 |
83 |
0.97 |
|
Size of nodules (no., %) | ||||||
| <2 (18, 4%) | 54 | 83 | 9 | 98 | 81 | 0.90 |
| ⩾2 (516, 96%) |
89 |
83 |
81 |
90 |
85 |
0.91 |
|
CLIP score | ||||||
| 0–1 (128, 24%) | 71 | 83 | 54 | 91 | 80 | 0.81 |
| ⩾2 (409, 76%) | 92 | 83 | 83 | 92 | 87 | 0.94 |
Abbreviations: AC=accuracy; AFP=α-fetoprotein; ART=α-fetoprotein-routine test; AUC=area under (ROC) curve; CLIP=Cancer of the Liver Italian Program; HCC=hepatocellular carcinoma; NPV=negative predictive value; PPV=positive predictive value; Sen=sensitivity; Spe=specificity.Simplified HCC-ART score=(log AFP × AST/ALT ratio × age × ALP (U l−1))/albumin (g l−1) at cutoff ⩾280.