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. 2013 Sep 3;109(6):1648–1656. doi: 10.1038/bjc.2013.488

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Copyright © 2013 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Heat-shock transcription factor-1 is expressed in HCC and matched peritumoral liver tissue and its expression in peritumoral liver tissue correlates with clinical outcomes of patients with HCC. (A) Hepatocellular carcinoma representative strong (case no. 17) and mild (case no. 58) immunostaining are shown for HSF1 in intratumoral (a, b) and peritumoral (c, d) tissue (scale bar, 100 μm). (B) Ten-year Kaplan–Meier survival plots of HSF1 for OS and TTR in peritumoral liver tissue and HCC tissue in cohort 1, and (C) peritumoral HSF1 for OS and TTR in validation cohort. Log-rank P-values associated with each dichotomisation are shown in the lower left of each plot.