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. 2013 Sep 3;109(6):1648–1656. doi: 10.1038/bjc.2013.488

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Copyright © 2013 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Effects of HSF1 alteration in peritumoral liver cells on proliferation and colonlisation of HCC cells, and the expression of MCT4. (A) Compared with that of L02-shNT cells, the supernatant of L02-shHSF1 cells in hypoxia condition significantly suppressed MHCC-97H colony formation and proliferation. (B) Using the supernatant in normoxia condition, there was no difference between colony formation and proliferation between two groups. (C) The specificity of shHSF1-mediated effects was further documented by reintroducing HSF1-cDNA engineered to be insensitive to shRNA. (D) In both normoxia and hypoxia culture conditions, silencing the expression of HSF1 led to low MCT4 expression.