Table 1. Univariate and multivariate analysis of factors associated with survival and recurrence.

	Overall survival				Time to recurrence
	Univariate	Multivariate			Univariate	Multivariate
Features	P-value	Hazard ratio	95% CI	P-value	P-value	Hazard ratio	95% CI	P-value
Age: <51 vs ⩾51 years	0.945			NA	0.589			NA
Gender: female vs male	0.186			NA	0.078			NA
Hepatitis B history: yes vs no	0.946			NA	0.807			NA
HBeAg: positive vs negative	0.338			NA	0.293			NA
Liver cirrhosis: yes vs no	0.006			NS	0.097			NA
AFP: <400 vs ⩾400 ng ml−1	0.003			NS	0.052			NA
Preoperative ALT: ⩽75 vs >75 U l−1	0.668			NA	0.409			NA
Tumour size: ⩽5 vs >5 cm	<0.001	1.90	1.03–3.53	0.042	<0.001			NS
Encapsulation: complete vs none	0.077			NA	0.086			NA
Microvascular invasion: yes vs no	0.017			NS	0.105			NA
Intrahepatic metastasis: yes vs no	<0.001			NS	0.001			NS
TNM stage: IIIa vs II vs I	<0.001	1.99	1.40–2.83	<0.001	<0.001	2.04	1.47–2.82	<0.001
Intratumoral HSF1 level: low vs high	0.067			NA	0.302			NA
Peritumoral HSF1 level: low vs high	<0.001	2.60	1.44–4.70	0.002	<0.001	2.52	1.51–4.19	<0.001

Abbreviations: AFP=α-fetoprotein; HSF1=heat-shock factor-1; MCT4=monocarboxylate transporter 4; NA=not adopted; NS=not significant; TNM=tumour node metastasis.

Note: Univariate analysis, Cox proportional hazards regression model. Bold values indicate P<0.05.