Table 3. Probabilistic sensitivity analyses correcting for non-differential and differential misclassification of breast cancer recurrence.
| Sensitivity analysisa | Odds ratio 2.5 percentile | Odds ratio median estimate | Odds ratio 97.5 percentile | Change in simulation interval width (b/a) compared with conventional (%) | Proportion of simulations with odds ratio<1 |
|---|---|---|---|---|---|
|
Persistence—low (⩾180 day gap) | |||||
|
Non-differential sensitivity analysisb | |||||
| Sensitivity analysis only | 2.45 | 3.98 | 7.78 | −51.5 | 0.010 |
| Sensitivity analysis with random error |
1.39 |
4.00 |
12.30 |
35.4 |
0.005 |
|
Differential sensitivity analysisc | |||||
| Sensitivity analysis only | 2.68 | 4.26 | 7.86 | −53.7 | 0.009 |
| Sensitivity analysis with random error |
1.51 |
4.29 |
12.79 |
34.1 |
0.003 |
|
Compliance–low (0%–90%) | |||||
|
Non-differential sensitivity analysisb | |||||
| Sensitivity analysis only | 1.00 | 1.36 | 1.90 | −37.2 | 0.222 |
| Sensitivity analysis with random error |
0.73 |
1.35 |
2.60 |
17.5 |
0.171 |
|
Differential sensitivity analysisc | |||||
| Sensitivity analysis only | 1.08 | 1.46 | 2.12 | −38.5 | 0.234 |
| Sensitivity analysis with random error |
0.77 |
1.46 |
2.81 |
19.8 |
0.124 |
|
Cumulative exposure—low (0%–90%) | |||||
|
Non-differential sensitivity analysisb | |||||
| Sensitivity analysis only | 1.32 | 1.80 | 2.61 | −35.7 | 0.048 |
| Sensitivity analysis with random error |
0.92 |
1.81 |
3.56 |
25.3 |
0.042 |
|
Differential sensitivity analysisc | |||||
| Sensitivity analysis only | 1.43 | 1.94 | 2.72 | −40.8 | 0.057 |
| Sensitivity analysis with random error | 1.01 | 1.96 | 3.67 | 13.1 | 0.024 |
5000 simulations.
Non-differential misclassification of breast cancer recurrence trapezoidal distributions: sensitivity (min=0.70, mode—1=0.75, mode—2=0.85, max=0.90); specificity (min=0.94, mode—1=0.96, mode—2=0.98, max=1.00).
Differential misclassification of breast cancer recurrence trapezoidal distributions: sensitivity: low compliance/persistence/exposure (min=0.70, mode—1=0.75, mode—2=0.85, max=0.90); sensitivity: high compliance/persistence/exposure (min=0.80, mode—1=0.85, mode—2=0.95, max=1.00); specificity: low compliance/persistence/exposure (min=0.94, mode—1=0.96, mode—2=0.98, max=1.00); specificity: high compliance/persistence/exposure (min=0.95, mode—1=0.97, mode—2=0.99, max=1.00); correlation between sensitivities and specificities 0.8.