Table 3.
Sensitivity and specificity for variant detection from different algorithms
| Program | Minor variants detected | Sensitivity | Specificity |
|---|---|---|---|
| PyroNoise | 5 | 0.4545 | 0.9957 |
| Acacia | 8 | 0.7273 | 0.9808 |
| Coral | 9 | 0.8182 | 0.9893 |
| QuRe | 8 | 0.7273 | 0.9976 |
| V-Phaser | 9 | 0.8182 | 0.9872 |
| ICC | 11 | 1 | 0.9827 |
Note: Sensitivity is reported as the fraction of the known variants found in the raw data by each correction algorithm. Specificity is reported as the fraction of sites not containing the known variants observed in the raw data. Variant calling required a frequency of ≥0.001 with total input copy number of 691 ± 310.