Table 2.

Receptor usage of VEGF family members and summary of their effects on iBREC proliferation and migration

Ligands	VEGF repceptors			Stimulation of
	VEGFR1	VEGFR2	Neuropilin-1	proliferation	migration
VEGF-A
VEGF121	+	+	−/+	Yes	No
VEGF165	+	+	+	Yes	Yes
PlGF
PlGF-1	+			Yes	No
PlGF-2	+		+	Yes	No
VEGF-E		+	+	Yes	Yes

+ binding and activation of receptor