Table 3.
Correlations of nuclear YAP with clinicopathological features in invasive breast cancer
| Feature | N | Nuclear YAP expression | ||
|---|---|---|---|---|
| Low (<20 %) N (%) | High (≥20 %) N (%) | p-value | ||
| Histologic type | ||||
| IDC | 187 | 140 (74.9) | 47 (25.1) | <0.001* |
| ILC | 50 | 12 (24.0) | 38 (76.0) | |
| Histologic grade | ||||
| 1 | 36 | 19 (52.8) | 17 (47.2) | 0.297 |
| 2 | 76 | 51 (67.1) | 25 (32.9) | |
| 3 | 125 | 82 (65.6) | 43 (34.4) | |
| Tumor size (cm) | ||||
| ≤2 | 108 | 79 (73.1) | 29 (26.9) | 1.451* |
| >2 and ≤5 | 98 | 60 (61.2) | 38 (38.8) | |
| >5 | 30 | 13 (43.3) | 17 (56.7) | |
| MAI (per 2 mm2) | ||||
| ≤12 | 103 | 61 (59.2) | 42 (40.8) | 0.167 |
| ≥13 | 134 | 91 (67.9) | 43 (32.1) | |
| Lymph node status | ||||
| Negative | 98 | 65 (66.3) | 33 (33.7) | 0.544 |
| Positive | 125 | 78 (62.4) | 47 (37.6) | |
*these data have been corrected for the difference in tumor size between IDC and ILC tumors