Fig. 2.

Effect of metformin treatment on trabecular and cortical bone parameters in tibia of 5-month-old ovariectomised wild-type mice. a, b, c Three-dimensionally computed BV/TV (a), trabecular number (b) and trabecular thickness (c) were assessed by micro-CT in the proximal tibial metaphysis of saline- and metformin-treated mice. d, e, f Two-dimensionally computed cortical thickness (d), periosteal perimeter (e) and endosteal perimeter (f) were assessed by micro-CT in the mid-diaphysis of cortical bone in saline- and metformin-treated mice. Bars represent mean ± SD of n = 9 mice/group