Table 1. MDM2 structure–activity relationships for purchased pyrroles 4a–l .

Compound	R1	R2	R3	R4	MDM2 IC50 (nM)
4a	4-ClPh	Me	H	H	720 ± 100
4b	4-ClPh	Me	H	Ph	3300 ± 700
4c	4-ClPh	Ph	H	H	120 ± 20
4d	4-ClPh	Ph	H	Ph	230 ± 44
4e	4-ClPh	Ph	H	3-ClPh	163 ± 17
4f	4-ClPh	Ph	3,4-diMePh	Ph	256 ± 39
4g	4-ClPh	Ph	Me	Me	Insol.
4h	4-BrPh	Me	Ph	Ph	199 ± 16
4i	4-MePh	Me	H	Ph	8400 ± 900
4j	4-MePh	Me	H	H	4700 ± 200
4k	4-EtO2CPh	Ph	H	H	700 ± 20