Table 5. Growth inhibitory activity of pyrroles 4c, 4r, 4t, 4x in a panel of cell lines with defined MDM2, MDMX and p53 status ^a .

Compound	GI50 (μM)
	SJSA-1	SN40R2 b	MRK-NU-1
4c c	2.3 ± 0.2	2.8 ± 0.6	2.3 ± 0.3
4r c	5.1 ± 0.9	5.9 ± 0.3	6.1 ± 0.7
4t c	4.7 ± 1.0	5.2 ± 0.4	4.9 ± 0.6
4x c	5.5 ± 0.6	6.3 ± 0.4	7.0 ± 1.0

^a n = 3.

^bp53 null.

^cResynthesised material.