Fig. 5.
Model simulations of the effects of varying IC50s and kd on cell death. The panels show simulations with different relative values for parameters IC50s, (a) and (b), and kd, (c) and (d), and within each panel, the drug concentration is varied relative to IC50g: [Cgem] = 0 (no drug), [Cgem] 10 % of IC50g, [Cgem] equal to IC50g, and [Cgem] 10-fold higher than IC50g. a Effect of highly drug-sensitive (100-fold lower) IC50s relative to IC50 of other cycle phases: IC50g = IC50m = 1,000 ng/mL, IC50s = 10 ng/mL, kd = 10−5 h−1 mL/ng, b IC50s equal to IC50 of other cycle phases, kd same as in a: IC50g = IC50s = IC50m = 1,000 ng/mL, kd = 10−5 h−1 mL/ng, c IC50 of cycle phases equal (same as in b), kd 1,000-fold lower than in a and b: IC50g = IC50s = IC50s = IC50m 1,000 ng/mL, kd = 10−8 h− mL/ng, and d IC50 of cycle phases equal (same as in b, c), kd 1,000-fold higher than in a and b: IC50g = IC50s = IC50m = 1,000 ng/mL, kd = 10−2 h−1 mL/ng