Table 1.
Model parameter estimates for different cell lines
| Cell line | Parameter | Definition | Value | CV (%) |
|---|---|---|---|---|
| AsPC-1 | k1 (h−1) | G1–S first-order rate transition | 0.04779 | 7.464 |
| k2 (h−1) | S–G2/M first-order rate transition | 0.06607 | 8.163 | |
| k3 (h−1) | G2/M–G1 first-order rate transition | 0.1381 | 10.09 | |
| IC50g (ng/mL) | G1 checkpoint sensitivity | 2,326 | 27.51 | |
| IC50s (ng/mL) | S checkpoint sensitivity | 1,066 | 21.84 | |
| IC50m (ng/mL) | G2/M checkpoint sensitivity | 5.71 × 106 | 4.79 × 104 | |
| kd (h−1 mL/ng) | Second-order rate transition into apoptosis | 8.22 × 10−13 | 4.14 × 108 | |
| BxPC-3 | k1 (h−1) | G1–S first-order rate transition | 0.03312 | 8.259 |
| k2 (h−1) | S–G2/M first-order rate transition | 0.05036 | 9.101 | |
| k3 (h−1) | G2/M–G1 first-order rate transition | 0.06779 | 9.572 | |
| IC50g (ng/mL) | G1 checkpoint sensitivity | 5.614 | 54.15 | |
| IC50s (ng/mL) | S checkpoint sensitivity | 0.8912 | 23.15 | |
| IC50m (ng/mL) | G2/M checkpoint sensitivity | 33.86 | 16.68 | |
| kd (h−1 mL/ng) | Second-order rate transition into apoptosis | 2.63 × 10−14 | 1.9 × 108 | |
| MiaPaca-2 | k1 (h−1) | G1–S first-order rate transition | 0.06315 | 4.49 |
| k2 (h−1) | S–G2/M first-order rate transition | 0.1202 | 6.27 | |
| k3 (h−1) | G2/M–G1 first-order rate transition | 0.1703 | 6.86 | |
| IC50g (ng/mL) | G1 checkpoint sensitivity | 4.445 | 57.21 | |
| IC50s (ng/mL) | S checkpoint sensitivity | 0.3097 | 17.50 | |
| IC50m (ng/mL) | G2/M checkpoint sensitivity | 6.546 | 30.75 | |
| kd (h−1 mL/ng) | Second-order rate transition into apoptosis | 4.69 × 10−13 | 6.75 × 108 |