Table 2.

The final parameter estimates and 95% CI from NONMEM and the bootstrap analyses^§

Parameter	NONMEM		Bootstrap Analysis
	Estimate	95% CI*	Median	95% CI†
CL/F (L/hr)	3.59	[3.39–3.79]	3.58	[3.39–3.80]
If taking PHT	1.23	[0.961–1.50]	1.26	[0.963–1.50]
V/F (L)	102	[37.1–167]	92.1	[19–189.6]
Ka (hr−1)	0.197	[0.0933–0.301]	0.19	[0.03–0.314]
IIV of CL/F (%CV)	18.1	[12.37–22.34]	17.92	[13.02–22.98]
IIV of V/F (%CV)	74.7	[21.1–103.44]	77.84	[1.06–121.24]
RUV, proportional (%CV)	25.1	[21.47–28.2]	24.6	[21.74–28.68]

^§From 747 bootstrap runs with a successful minimization and successful covariance step

^*(Estimate) ± 1.96 × (standard error of the estimate)

^†2.5th and 97.5th percentile of the ranked bootstrap parameter estimates