Table 2.

MTNR1a, MTNR1b, and AANAT SNPs and breast cancer risk among all women, the Shanghai Breast Cancer Study

Gene	SNP	MAFa	HWEb	OR-hetc	OR-homc	P-trend	OR-dominantc	P-dominant	OR-recessivec	P-recessive
MTNR1a	rs6838290	0.0708	0.25	1.10(0.91– 1.32)	0.64(0.26– 1.54)	0.6119	1.07(0.89– 1.29)	0.4485	0.63(0.26– 1.52)	0.3034
	rs2165667	0.3168	0.29	1.04(0.91– 1.18)	1.08(0.88– 1.32)	0.4125	1.05(0.93– 1.18)	0.4513	1.06(0.87– 1.29)	0.5805
	rs6847693	0.3890	0.57	1.00(0.87– 1.15)	1.15(0.95– 1.39)	0.2130	1.04(0.91– 1.19)	0.5516	1.15(0.97– 1.36)	0.1128
	rs2165666	0.3176	0.23	1.03(0.91– 1.17)	1.07(0.88– 1.32)	0.4604	1.04(0.92– 1.18)	0.5253	1.06(0.87– 1.29)	0.5698
	rs7665392	0.2260	0.45	0.94(0.82– 1.08)	1.05(0.78– 1.41)	0.6593	0.95(0.84– 1.08)	0.4619	1.07(0.80– 1.43)	0.6424
	rs12642043	0.6512	0.88	0.91(0.75– 1.10)	0.86(0.71– 1.04)	0.1204	0.88(0.74– 1.06)	0.1742	0.93(0.82– 1.05)	0.2229
	rs4861722	0.2111	0.14	1.11(0.97– 1.27)	1.17(0.88– 1.54)	0.0792	1.12(0.99– 1.27)	0.0798	1.13(0.86– 1.48)	0.3981
	rs10030173	0.4819	0.31	0.98(0.84– 1.13)	0.89(0.74– 1.06)	0.2007	0.95(0.82– 1.09)	0.4505	0.90(0.78– 1.05)	0.1741
MTNR1b	rs10830962	0.4287	0.95	1.08(0.94– 1.24)	1.04(0.87– 1.24)	0.5484	1.07(0.94– 1.22)	0.3133	0.99(0.84– 1.16)	0.8924
	rs10765576	0.2948	0.09	1.04(0.91– 1.19)	0.79(0.63– 0.99)	0.2823	0.99(0.87– 1.12)	0.8774	0.78(0.62– 0.97)	0.0281
	rs10830963	0.4224	0.61	1.14(0.99– 1.32)	1.04(0.86– 1.25)	0.4252	1.12(0.97– 1.28)	0.1133	0.96(0.81– 1.13)	0.6251
	rs4611171	0.3023	0.54	0.97(0.85– 1.10)	0.85(0.68– 1.06)	0.2020	0.95(0.84– 1.07)	0.3818	0.86(0.69– 1.07)	0.1715
AANAT	rs8150	0.3547	0.46	1.07(0.93– 1.22)	1.16(083 1.39)	0.5699	1.09(0.96– 1.24)	0.2038	1.12(0.92– 1.35)	0.2525
	rs3826287	0.3474	0.96	1.10(0.96– 1.26)	1.19(0.97– 1.46)	0.3164	1.12(0.98– 1.27)	0.0869	1.13(0.93– 1.36)	0.2274

^aMinor allele frequency among genotyped controls

^bHardy-Weinberg equibrium among genotyped controls

^cORs adjusted for age, education, and study stage.