Table 1.
Dopaminergic genes and SNPs analyzed
| Gene | Location | Gene name (alias name) | Size (kb) | SNPs genotyped | ||
|---|---|---|---|---|---|---|
| Stage I | Stage II | Stage III | ||||
| COMT | 22q11.2 | Catechol-O-methyltransferase | 27.2 | 7 | 18 | 17 |
| DBH | 9q34 | Dopamine beta hydroxylase | 23.0 | 9 | ||
| DDC | 7p11 | Dopamine decarboxylase | 102.6 | 5 | ||
| DRD1 | 5q35.1 | Dopamine D1 receptor | 3.1 | 3 | ||
| DRD1IP | 10q26.3 | D1 receptor-interacting protein (CALCYON) | 11.5 | 5 | ||
| DRD2 | 11q23 | Dopamine D2 receptor | 65.6 | 5 | ||
| DRD3 | 3q13.3 | Dopamine D3 receptor | 50.2 | 13a | 18 | 18 |
| DRD4 | 11p15.5 | Dopamine D4 receptor | 3.4 | 3 | ||
| DRD5 | 4p16.1 | Dopamine D5 receptor | 2.1 | 3 | ||
| MAOA | Xp11.3 | Monoamine oxidase A | 90.6 | 10 | ||
| MAOB | Xp11.3 | Monoamine oxidase B | 115.8 | 6 | ||
| NR4A2 | 2q24.1 | Orphin nuclear receptor subunit 4 (NURR1) | 8.3 | 5 | ||
| PPP1R1B | 17q21.2 | Protein phosphatase 1, regulatory (inhibitory) subunit 1B (DARPP-32) | 9.7 | 4 | ||
| SLC18A1 | 8p21.3 | Vessicular monoamine transporter, member 1 (VMAT1) | 38.4 | 10 | ||
| SLC18A2 | 10q25 | Vessicular monoamine transporter, member 2 (VMAT2) | 35.9 | 3 | 14 | 13 |
| SLC6A2 | 16q12.2 | Monoamine transporter, noradrenaline (NET) | 46.0 | 8 | ||
| SLC6A3 | 5p15.3 | Dopamine transporter (DAT, DAT1) | 52.6 | 6 | 18 | 17 |
| TH | 11p15.5 | Tyrosine hydroxylase | 7.9 | 3 | ||
Dopamine genes and SNPs analyzed are given in alphabetical order. The boldfaced genes were further analyzed in stages II and III.
a
These SNPs were previously analyzed and results from those published analyses suggested significant associations in these samples (20).