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. Author manuscript; available in PMC: 2013 Sep 19.
Published in final edited form as: J Endocrinol. 2009 Dec 23;204(3):287–297. doi: 10.1677/JOE-09-0183

Figure 1. Activation of the CaR stimulates cAMP accumulation and PTHrP and ACTH Secretion.

Figure 1

A) Intracellular cAMP levels in AtT-20 cells treated with 0.1 mM, 2.5 mM or 5 mM extracellular calcium and neomycin (300 μM). B) PTHrP levels were increased in conditioned media from cells treated with 2.5 mM or 5 mM calcium or neomycin. C) ACTH levels were increased in conditioned media from cells treated with extracellular calcium or neomycin. Bars represent the means ± S.E. of three independent experiments. Statistical significance (p<0.05) is noted on the graphs: a denotes a significant difference compared with 0.1mM calcium, b denotes a significant difference compared with 2.5mM calcium and c denotes a significant difference as compared with 5mM calcium.