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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Kidney Int. 2013 Mar 20;84(2):308–316. doi: 10.1038/ki.2013.97

Figure 7. Proposed Scheme: CKD-induced stimulation of SIRP-α impairs insulin signaling and induces muscle wasting.

Figure 7

CKD-induced cytokines stimulate NF-κB activation, allowing for increased expression of SIRP-α proteins. Stimulation of SIRP-α triggers tyrosine de-phosphorylation of IRS-1 and insulin receptor, leading to a reduction in p-Akt and finally muscle protein loss.