Table 5. Stratified analysis of factors influencing FISH-positive phenotype in patients with NSCLC.
| Variable | EGFR mutation | FISH-positive phenotype [cases (%)] |
P | |
| High polysomy | Amplification | |||
| Gender | ||||
| Male | - | 45 (77) | 13 (59) | 0.127 |
| + | 14 (23) | 9 (41) | ||
| Female | - | 13 (41) | 0 (0) | 0.004 |
| + | 19 (59) | 15 (100) | ||
| Age (years) | ||||
| ≥ 59 | - | 34 (64) | 10 (56) | 0.516 |
| + | 19 (36) | 8 (44) | ||
| <59 | - | 24 (63) | 3 (16) | 0.001 |
| + | 14 (37) | 16 (84) | ||
| Smoking status | ||||
| Ever | - | 44 (86) | 12 (63) | 0.045 |
| + | 7 (14) | 7 (37) | ||
| Never | - | 14 (35) | 1 (6) | 0.023 |
| + | 26 (65) | 17 (94) | ||
| Histological type | ||||
| ADC | - | 35 (52) | 8 (27) | 0.019 |
| + | 32 (48) | 22 (73) | ||
| Non-ADC | - | 23 (96) | 5 (71) | 0.120 |
| + | 1 (4) | 2 (29) | ||
| Differentiation | ||||
| Grade 1 | - | 5 (83) | 0 (0) | 0.048 |
| + | 1 (17) | 3 (100) | ||
| Grade >1 | - | 53 (62) | 13 (38) | 0.017 |
| + | 32 (38) | 21 (62) | ||
| Stage | ||||
| Early (IA+IB) | - | 24 (65) | 2 (22) | 0.029 |
| + | 13 (35) | 7 (78) | ||
| Medium (IIA+IIB+IIIA) | - | 25 (64) | 8 (47) | 0.233 |
| + | 14 (36) | 9 (53) | ||
| Advanced (IIIB+IV) | - | 9 (60) | 3 (27) | 0.098 |
| + | 6 (40) | 8 (73) | ||
Abbreviations as in Table 1.