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. 2012 Apr;31(4):169–177. doi: 10.5732/cjc.011.10319

Figure 1. Skp2 belongs to the F-box protein family.

Figure 1.

A, a simplified scheme for the ubiquitin proteasome system. Posttranslational modification of a protein with ubiquitin is mediated by three enzymes: the E1-activating enzyme, the E2-conjugating enzyme, and the E3 ligase. B, SCF E3 ligase complex is composed of Cul-1, Skp1, Roc1, and an F-box protein, such as Skp2. C, F-box proteins can be divided into three classes, WD40 repeat-containing F-box proteins (FBXWs), leucine-rich repeats (LRRs)-containing F-box proteins (FBXLs) including Skp2, and F-box proteins containing other diverse domains (FBXOs).