Table 1. Resistance to tyrosine kinase inhibitors (TKIs) mediated by ATP-binding cassette (ABC) transporters.

TKI	Alternative name(s)	ABC transporters linked to TKI resistance	Reference(s)
Imatinib	Gleevec, STI571	ABCG2/BCRP, ABCB1/P-gp/MDR1, ABCC1/MRP1	[21], [22], [30], [31], [33]
Nilotinib	Tasigna, AMN107	ABCG2/BCRP, ABCB1/P-gp/MDR1	[22], [23], [32]
Dasatinib	BMS-354825	ABCG2/BCRP, ABCB1/P-gp/MDR1	[23], [24]
Gefitinib	Iressa, ZD1839	ABCG2/BCRP	[25]-[27]
EKI-785	EKI-785	ABCG2/BCRP	[25], [26]
Danusertib	PHA-739358	ABCG2/BCRP	[28]
Canertinib	CI1033	ABCG2/BCRP	[29]
Sorafenib	Nexavar	ABCC2/MRP2	[34]

EKI-785, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide.