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A, summary of mutations in FAN1. B, U2OS cells transfected with wild-type FAN1 or mutant FAN1 for 24 h were treated with 20 µg/mL cycloheximide and collected at the indicated time points for western blotting. C, the densities of the FAN1 protein bands at each time point were normalized to GAPDH and were calculated into percentages using 1.0 as the value of the zero time point.
