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Under normoxic conditions, YC-1 inhibited EGFR mRNA expression in a dose-dependent manner (A); YC-1 (1 µmol/L) also inhibited the expression of EGFR and STAT3 and blocked STAT3 phosphorylation (B). Under hypoxic conditions, only 10 µmol/L YC-1 inhibited EGFR mRNA (C) and protein expression (D). *P < 0.05, **P < 0.01, ***P < 0.001, vs. control.
