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. 2012 May;31(5):248–256. doi: 10.5732/cjc.011.10383

Figure 5. Effect of YC-1 on the mouse xenograft model.

Figure 5.

A, compared with control, 30 and 100 mg/kg of YC-1 significantly inhibited tumor growth. Notably, tumor volume in the 100 mg/kg YC-1 group was not augmented. B, in vivo optical imaging revealed that the tumor volume in the 100 mg/kg YC-1 group decreased over time. C, all control mice died by the 24th week. At the 40th week, about 40% of mice in the 30 mg/ kg YC-1 group and 90% of mice in the 100 mg/kg YC-1 group were alive. D, all control mice had metastasis at the 19th week, but neither YC-1 treatment group had metastasis at that time. At the 36th week, about 70% of mice in the 30 mg/kg YC-1 group had metastasis, but metastasis was observed in only 10% of mice in the 100 mg/kg YC-1 group. E, body weight was not different among groups. F, compared with control, 30 and 100 mg/kg of YC-1 inhibited both EGFR and HIF-1α expression.