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. Author manuscript; available in PMC: 2013 Sep 19.
Published in final edited form as: Nat Med. 2012 Sep 16;18(10):1503–1510. doi: 10.1038/nm.2941

Figure 3. Cellular proliferation is inhibited by NRASQ61K extinction, but not MEK inhibition.

Figure 3

(a) Representative immunofluorescence staining of iNRAS-413 melanoma allografts to measure proliferation by phospho-histone-H3 (pH3) and apoptosis by TUNEL staining. See also Supplementary Fig. 1b. (b,c) Quantitation of (b) pH3 and (c) TUNEL positivity in iNRAS-413 allografts. (d,e)Quantitation of (d) pH3 and (e) TUNEL positivity in iNRAS-475 allografts. Two-tailed student’s t-tests were used to calculate p-values. All error bars are SEM.