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. Author manuscript; available in PMC: 2013 Sep 19.
Published in final edited form as: Nat Med. 2012 Sep 16;18(10):1503–1510. doi: 10.1038/nm.2941

Figure 5. Combination MEK and CDK4/6 Inhibition is synergistic in vivo.

Figure 5

(a)Mouse cell line iNRAS-413 allografts treated singly or in combination with PD0332991 and AZD6244. All error bars in this figure are SEM. (b)Mouse cell line iNRAS-475 allografts treated singly or in combination with PD0332991 and GSK1120212. Doxycycline withdrawal is shown for comparison. QD: daily. QOD: every other day. (c)Human NRAS*-mutant cell line HMVII xenografts treated singly or in combination with PD0332991 and GSK1120212. (d,e)Quantification of (d) phospho-histone-3 and (e) TUNEL positivity in HMVII tumors after 8 days of treatment.