Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Sep;72(9):824–832. doi: 10.1097/NEN.0b013e3182a0a39f

Figure 1.

Figure 1

CSF Tau cleaved by caspase-6 (TauΔCasp6) levels correlate with TauΔCasp6 levels in the brain. (A) Micrographs of hippocampi immunostained with anti-TauΔCasp6 (upper panels) or anti-active Casp6 (lower panels) demonstrate variable abundance of pathological Tau immunoreactivity on which pathological scores of 0 to 3 were assigned. (B) Example of 2 standard curves obtained by ELISA with recombinant TauΔCasp6 and full-length (FL) Tau confirm the specificity of the assay for TauΔCasp6. (C, D) Spearman rank correlation (r) between the levels of TauΔCasp6 in CSF and TauΔCasp6 (C) or active caspase-6 (D) immunostaining scores in samples from the indicated brain regions. *p < 0.05, **p < 0.01. Trans-ERC, trans-entorhinal cortex; ERC, entorhinal cortex.