. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2013 Sep;72(9):824–832. doi: 10.1097/NEN.0b013e3182a0a39f

Table 2.

Regression analysis predicting cognition from Tau cleaved by caspase 6 cerebrospinal fluid levels and brain pathology

	Model	Estimate (SE)	p value	Beta	Constant (SE)	Adjusted R²
Global Cognitive Score	ERC +	−0.638 (0.469)	0.006	−0.579
Global Cognitive Score	CSF	−0.007 (0.003)	0.041	−0.400	1.519 (0.512)	0.670
MMSE	CSF +	−0.072 (0.021)	0.004	−0.556
MMSE	CA2	−4.190 (1.368)	0.010	−0.484	37.974 (3.673)	0.698
Episodic Memory	ERC	−1.113 (0.219)	<0.0001	−0.815	1.368 (0.528)	0.639
Semantic Memory	SUB +	−0.521 (0.194)	0.020	−0.500
Semantic Memory	CSF	−0.008 (0.003)	0.030	−0.459	1.324 (0.537)	0.620
Working Memory	Age	−0.096 (0.028)	0.004	−0.696	7.333 (2.398)	0.445

In the model column, the CSF Tau cleaved by Casp6 (TauΔCasp6) is indicated by “CSF”; the pathological TauΔCasp6 score is indicated by brain area as follows: ERC, entorhinal cortex; SUB, subiculum. CSF, cerebrospinal fluid; MMSE, Mini-mental state examination; SE, standard error.

Data represent statistic parameters for predictor variables of the various models.