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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Nat Genet. 2013 Jun 9;45(7):784–790. doi: 10.1038/ng.2656

Figure 5. A representative Lineage 2 strain acquires isoniazid and ethambutol resistance at a higher rate.

Figure 5

Fluctuation analysis was used to determine the isoniazid (1μg/mL) and ethambutol (5μg/mL) resistance rate for the Lineage 4 strain, CDC1551, (shown in red) and the Lineage 2 strain, HN878 (shown in blue). Circles represent mutation frequency (number of mutants per cell in a single culture), where darker circles represent multiple cultures with the same frequency. Bars represent the estimated mutation rate, with error bars representing the 95% confidence interval. Significance was determined by non-overlapping 95% confidence interval. Values are listed in Supplementary Table 1.