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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Diabetes Obes Metab. 2013 Sep;15(0 3):105–116. doi: 10.1111/dom.12160

Fig. 4. Intraocular pancreatic islet grafts are revascularized by existing blood vessels of the iris.

Fig. 4

Representative confocal micrograph a pancreatic islet transplanted in the anterior chamber of a mouse eye showing rich revascularization of the islet by existing iris blood vessels. The left panels show the islet graft visualized by laser backscatter (reflection), blood vessels visualized by injection of TRITC-labeled dextran, and infiltrating GFP-labeled T cells. The image on the right shows an overlay of the three images on the left. Revascularization of pancreatic islets in the anterior chamber of the eye contributes to breaking immune privilege and leads to precipitation of typical immune responses similar to those observed at other ectopic transplantation sites.