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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Diabetes Obes Metab. 2013 Sep;15(0 3):159–169. doi: 10.1111/dom.12163

Figure 2. Mechanism of eIF2α-mediated translation initiation.

Figure 2

The GDP bound to eIF2α is exchanged for GTP by eIF2B, allowing for eIF2α to recycle and permit translation initiation. When eIF2α is phosphorylated by the enzyme PERK, which itself is activated by ER stress, the bound GDP can no longer exchange with GTP and translation initiation is blocked.