Fig. 2.

Construction of affected track and calculation of false discovery rate in diffusion MRI connectometry. (A) Local tract orientations with percentile ranks lower than a threshold are connected by a fiber tracking algorithm to reveal the affected tracks in patients. (B) The length distribution of the affected tracks follows an exponential distribution in normal population, whereas that in patients is shifted to the right. (C) The affected tracks with length greater than a length threshold (e.g. 10 voxel distance in this case) can be regarded as positive findings. The false discovery rate can be calculated by the area ratio between the two length distribution curves.