Fig. S1.
Two-year atrophy rates based on a statistically defined region-of-interest in the temporal lobes of a mixture of MCI and cognitively normal (N = 394) are negatively correlated with the 2-year change in sum-of-boxes Clinical Dementia Rating scores (ΔCDR-SOB) with R2 = 0.25; p < 2 × 10− 16. The scores are defined as the sum of memory, problem solving, orientation, community affairs, home and hobbies, and personal care. Negative values for atrophy rates reflect stronger atrophy, which correlate with change toward higher CDR-SOB scores (i.e., clinically worsening dementia). The correlation significance was unchanged after covarying for age and sex.