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. 2013 Jun 13;2:827–835. doi: 10.1016/j.nicl.2013.05.007

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig. S2 — As in Fig. 1, sample size estimates (n80) are shown for a hypothetical clinical trial with a mixture of healthy control and mild cognitive impairment (MCI) subjects, as a function of number of subjects (N) after ranking subjects according to a cumulative genetic risk score derived from ApoE4 and single nucleotide polymorphisms in CLU, CR1 and PICALM (blue). Here, ApoE is coded as 0, 1 or 2 corresponding to the number of ε4 alleles. Permutations are performed by randomizing the ranking procedure 1000 times and calculating n80 estimates for each N (all permuted estimates are shown in black). Selection of ApoE ε4/ε4 subjects (a subset of 35 subjects) reduces n80s from 142 to 52. Although the number of subjects is limited, selecting fractions of ApoE ε4/ε4 individuals with higher cumulative genetic risk scores helps further reduce n80s to ~ 35.