Table 1.
Clinicopathologic and treatment characteristics of patients undergoing interdigitated neoadjuvant chemoradiotherapy (N=66)
| n (%) | ||
|---|---|---|
| Gender | ||
| Male | 50 (76) | |
| Age at diagnosis (years) | ||
| Mean | 51 | |
| Median | 53 | |
| Range | 18–73 | |
| Primary vs. recurrent at presentation | ||
| Primary | 63 (95) | |
| Recurrent | 3 (5) | |
| Histology | ||
| Undifferentiated high grade pleomorphic sarcoma | 23 (35) | |
| Liposarcoma | 20 (30) | |
| Synovial sarcoma | 12 (18) | |
| Myxofibrosaroma | 6 (9) | |
| Malignant peripheral nerve sheath tumor | 3 (4) | |
| Myofibroblastic sarcoma | 1 (2) | |
| Angiosarcoma | 1 (2) | |
| Location | ||
| Thigh | 36 (55) | |
| Lower leg | 8 (12) | |
| Axilla/Shoulder | 7 (11) | |
| Buttock | 5 (8) | |
| Arm | 4 (6) | |
| Popliteal space | 2 (3) | |
| Foot | 1 (2) | |
| Back | 1 (2) | |
| Elbow | 1 (2) | |
| Scapula | 1 (2) | |
| Pathologic dimension (cm) | ||
| Mean | 12 | |
| Median | 10 | |
| Range | 2.5–35.5 | |
| Histologic grade | ||
| 1 | 0 (0) | |
| 2 | 33 (50) | |
| 3 | 33 (50) | |
| Surgical margin* | ||
| Negative (≥ 1mm) | 38 (58) | |
| Close (< 1mm) | 19 (29) | |
| Positive | 7 (11) | |
| Percent necrosis* | ||
| 0–25 % | 10 (15) | |
| 26–50 % | 5 (8) | |
| 51–75 % | 12 (18) | |
| 76–100 % | 35 (53) | |
| Unknown | 4 (6) | |
| Extent of resection* | ||
| Radical resection | 62 (94) | |
| Wide local excision | 1 (2) | |
| Amputation | 1 (2) | |
| Surgical reconstruction | 18 (27) ** | |
| Pedicled flap +/− STSG | 8 (12) | |
| Free flap + STSG | 2 (3) | |
| Complex primary closure | 4 (6) | |
| Prophylactic long bone fixation | 5 (8) | |
STSG: Split thickness skin graft, NA: Neoadjuvant, IORT Intraoperative radiation therapy,
*
2 patients did not receive surgery,
**
1 patient underwent prophylactic fixation + sartorius muscle flap.