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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Dev Biol. 2013 Jul 23;381(2):301–311. doi: 10.1016/j.ydbio.2013.07.016

Figure 2. Expression of Bmp2, Bmp4, and Bmp7 in developing Meckel’s cartilage.

Figure 2

(A–C) In situ hybridization shows Bmp2 and Bmp7 but not Bmp4 expression in mesenchymal condensation of Meckel’s cartilage at E11.5. Note Bmp2 expression in the dental epithelium (arrow in panel A) and Bmp4 expression in the dental mesenchyme (arrow in panel B). (D–F) At E12.5, strong Bmp2 expression and relatively weaker Bmp7 expression but not Bmp4 is detected in Meckel’s cartilage. In addition, all three Bmp genes are expressed in the surrounding mesenchymal tissues. (G–O) At E13.5 and subsequently developmental stages at E14.5 and E16.5, these Bmp genes are no longer expressed in Meckels’ cartilage but are expressed at lower levels in the surrounding mesenchymal tissues and developing mandibular bone. M, Meckel’s cartilage; T, tooth; Mb, mandibular bone; Sek, secondary enamel knot. Scale bar = 100-μm.