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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Dev Biol. 2013 Jul 23;381(2):301–311. doi: 10.1016/j.ydbio.2013.07.016

Figure 8. Activation of BMPRIa-mediated BMP signaling in chondrocyte-lineage resembles Nog−/− Meckel’s cartilage phenotype.

Figure 8

(A) X-gal staining shows Cre activity in chondrocytes of Meckel’s cartilage of an E14.0 Col2a1-CreERT2;R26R embryo that received an administration of tamoxifen at E12.5. (B) A coronal section of an E16.5 Col2a1-CreERT2;pMes-caBmprIb embryo shows unaffected Meckel’s cartilage. (C, D) Coronal sections E15.5 Col2a1-CreERT2;pMes-caBmprIa embryos show significantly enlarged Meckel’s cartilage. (E, F) In situ hybridization assay shows Ihh expression (E) and Col X expression (F) in enlarged Meckel’s cartilage of E15.5 Col2a1-CreERT2;pMes-caBmprIa embryo. M, Meckel’s cartilage; T, tooth. Scale bar = 100-μm.